<?xml version="1.0" encoding="UTF-8"?><CodeSystem xmlns="http://hl7.org/fhir"><id value="v3-substanceAdminSubstitution"/><language value="en"/><text><status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en"><p class="res-header-id"><b>Generated Narrative: CodeSystem v3-substanceAdminSubstitution</b></p><a name="v3-substanceAdminSubstitution"> </a><a name="hcv3-substanceAdminSubstitution"> </a><a name="v3-substanceAdminSubstitution-en-US"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Language: en</p></div><p><b>Properties</b></p><p><b>This code system defines the following properties for its concepts</b></p><table class="grid"><tr><td><b>Name</b></td><td><b>Code</b></td><td><b>URI</b></td><td><b>Type</b></td><td><b>Description</b></td></tr><tr><td>Specializes</td><td>Specializes</td><td/><td>Coding</td><td>The child code is a more narrow version of the concept represented by the parent code.  I.e. Every child concept is also a valid parent concept.  Used to allow determination of subsumption.  Must be transitive, irreflexive, antisymmetric.</td></tr><tr><td>Generalizes</td><td>Generalizes</td><td/><td>Coding</td><td>Inverse of Specializes.  Only included as a derived relationship.</td></tr><tr><td>internalId</td><td>internalId</td><td>http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id</td><td>code</td><td>The internal identifier for the concept in the HL7 Access database repository.</td></tr><tr><td>Not Selectable</td><td>notSelectable</td><td>http://hl7.org/fhir/concept-properties#notSelectable</td><td>boolean</td><td>Indicates that the code is abstract - only intended to be used as a selector for other concepts</td></tr><tr><td>Status</td><td>status</td><td>http://hl7.org/fhir/concept-properties#status</td><td>code</td><td>Designation of a concept's state. Normally is not populated unless the state is retired.</td></tr></table><p><b>Concepts</b></p><p>This case-sensitive code system <code>http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution</code> defines the following codes in a Is-A hierarchy:</p><table class="codes"><tr><td><b>Lvl</b></td><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td><td><b>internalId</b></td><td><b>Not Selectable</b></td><td><b>Status</b></td></tr><tr><td>1</td><td style="white-space:nowrap">_ActSubstanceAdminSubstitutionCode<a name="v3-substanceAdminSubstitution-_ActSubstanceAdminSubstitutionCode"> </a></td><td>ActSubstanceAdminSubstitutionCode</td><td><div><p>Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects.</p>
</div></td><td>21284</td><td>true</td><td>active</td></tr><tr><td>2</td><td style="white-space:nowrap">  E<a name="v3-substanceAdminSubstitution-E"> </a></td><td>equivalent</td><td><div><p>Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product.</p>
</div></td><td>23107</td><td/><td>active</td></tr><tr><td>3</td><td style="white-space:nowrap">    EC<a name="v3-substanceAdminSubstitution-EC"> </a></td><td>equivalent composition</td><td><div><p>Substitution occurred or is permitted with another product that is a:</p>
<ul>
<li>pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester</li>
<li>pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration</li>
</ul>
<p><em>Examples:</em></p>
<ul>
<li><em>Pharmaceutical alternative:</em> Erythromycin Ethylsuccinate for Erythromycin Stearate</li>
<li><em>Pharmaceutical equivalent:</em> Lisonpril for Zestril</li>
</ul>
</div></td><td>23108</td><td/><td>active</td></tr><tr><td>4</td><td style="white-space:nowrap">      BC<a name="v3-substanceAdminSubstitution-BC"> </a></td><td>brand composition</td><td><div><p>Substitution occurred or is permitted between equivalent Brands but not Generics</p>
<p><em>Examples:</em></p>
<ul>
<li>Zestril for Prinivil</li>
<li>Coumadin for Jantoven</li>
</ul>
</div></td><td>23109</td><td/><td>active</td></tr><tr><td>4</td><td style="white-space:nowrap">      G<a name="v3-substanceAdminSubstitution-G"> </a></td><td>generic composition</td><td><div><p>Substitution occurred or is permitted between equivalent Generics but not Brands</p>
<p><em>Examples:</em></p>
<ul>
<li>Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)</li>
</ul>
</div></td><td>16623</td><td/><td>active</td></tr><tr><td>3</td><td style="white-space:nowrap">    TE<a name="v3-substanceAdminSubstitution-TE"> </a></td><td>therapeutic alternative</td><td><div><p>Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.</p>
<p><em>Examples:</em></p>
<ul>
<li>ranitidine for Tagamet</li>
</ul>
</div></td><td>16624</td><td/><td>active</td></tr><tr><td>4</td><td style="white-space:nowrap">      TB<a name="v3-substanceAdminSubstitution-TB"> </a></td><td>therapeutic brand</td><td><div><p>Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics</p>
<blockquote>
</blockquote>
<p><em>Examples:</em></p>
<ul>
<li>Zantac for Tagamet</li>
</ul>
</div></td><td>23105</td><td/><td>active</td></tr><tr><td>4</td><td style="white-space:nowrap">      TG<a name="v3-substanceAdminSubstitution-TG"> </a></td><td>therapeutic generic</td><td><div><p>Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands</p>
<blockquote>
</blockquote>
<p><em>Examples:</em></p>
<ul>
<li>Ranitidine for cimetidine</li>
</ul>
</div></td><td>23106</td><td/><td>active</td></tr><tr><td>2</td><td style="white-space:nowrap">  F<a name="v3-substanceAdminSubstitution-F"> </a></td><td>formulary</td><td><div><p>This substitution was performed or is permitted based on formulary guidelines.</p>
</div></td><td>16625</td><td/><td>active</td></tr><tr><td>2</td><td style="white-space:nowrap">  N<a name="v3-substanceAdminSubstitution-N"> </a></td><td>none</td><td><div><p>No substitution occurred or is permitted.</p>
</div></td><td>16622</td><td/><td>active</td></tr></table></div></text><url value="http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution"/><identifier><system value="urn:ietf:rfc:3986"/><value value="urn:oid:2.16.840.1.113883.5.1070"/></identifier><version value="3.0.0"/><name value="SubstanceAdminSubstitution"/><title value="Substance Admin Substitution"/><status value="active"/><experimental value="false"/><date value="2019-03-20"/><publisher value="Health Level Seven International"/><contact><telecom><system value="url"/><value value="http://hl7.org"/></telecom><telecom><system value="email"/><value value="hq@HL7.org"/></telecom></contact><description value="Identifies what sort of change is permitted or has occurred between the therapy that was ordered and the therapy that was/will be provided."/><copyright value="This material derives from the HL7 Terminology THO. THO is copyright ©1989+ Health Level Seven International and is made available under the CC0 designation. For more licensing information see: https://terminology.hl7.org/license.html"/><caseSensitive value="true"/><hierarchyMeaning value="is-a"/><content value="complete"/><property><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry"><valueCode value="antisymmetric"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity"><valueCode value="transitive"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity"><valueCode value="irreflexive"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable"><valueBoolean value="true"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind"><valueCode value="Specializes"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName"><valueString value="Generalizes"/></extension><code value="Specializes"/><description value="The child code is a more narrow version of the concept represented by the parent code.  I.e. Every child concept is also a valid parent concept.  Used to allow determination of subsumption.  Must be transitive, irreflexive, antisymmetric."/><type value="Coding"/></property><property><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry"><valueCode value="antisymmetric"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity"><valueCode value="transitive"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity"><valueCode value="irreflexive"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable"><valueBoolean value="true"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind"><valueCode value="Generalizes"/></extension><extension url="http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName"><valueString value="Specializes"/></extension><code value="Generalizes"/><description value="Inverse of Specializes.  Only included as a derived relationship."/><type value="Coding"/></property><property><code value="internalId"/><uri value="http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id"/><description value="The internal identifier for the concept in the HL7 Access database repository."/><type value="code"/></property><property><code value="notSelectable"/><uri value="http://hl7.org/fhir/concept-properties#notSelectable"/><description value="Indicates that the code is abstract - only intended to be used as a selector for other concepts"/><type value="boolean"/></property><property><code value="status"/><uri value="http://hl7.org/fhir/concept-properties#status"/><description value="Designation of a concept's state. Normally is not populated unless the state is retired."/><type value="code"/></property><concept><code value="_ActSubstanceAdminSubstitutionCode"/><display value="ActSubstanceAdminSubstitutionCode"/><definition value="Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects."/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="ActSubstanceAdminSubstitutionCode"/></designation><property><code value="notSelectable"/><valueBoolean value="true"/></property><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="21284"/></property><concept><code value="E"/><display value="equivalent"/><definition value="Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product."/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="equivalent"/></designation><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="23107"/></property><concept><code value="EC"/><display value="equivalent composition"/><definition value="Substitution occurred or is permitted with another product that is a:&#xD;&#xA;&#xD;&#xA; *  pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester&#xD;&#xA; *  pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration&#xD;&#xA;&#xD;&#xA;*Examples:* &#xD;&#xA;&#xD;&#xA; *  *Pharmaceutical alternative:* Erythromycin Ethylsuccinate for Erythromycin Stearate&#xD;&#xA; *  *Pharmaceutical equivalent:* Lisonpril for Zestril"/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="equivalent composition"/></designation><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="23108"/></property><concept><code value="BC"/><display value="brand composition"/><definition value="Substitution occurred or is permitted between equivalent Brands but not Generics&#xD;&#xA;&#xD;&#xA;*Examples:* &#xD;&#xA;&#xD;&#xA; *  Zestril for Prinivil&#xD;&#xA; *  Coumadin for Jantoven"/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="brand composition"/></designation><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="23109"/></property></concept><concept><code value="G"/><display value="generic composition"/><definition value="Substitution occurred or is permitted between equivalent Generics but not Brands&#xD;&#xA;&#xD;&#xA;*Examples:* &#xD;&#xA;&#xD;&#xA; *  Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)"/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="generic composition"/></designation><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="generic composition"/></designation><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="16623"/></property></concept></concept><concept><code value="TE"/><display value="therapeutic alternative"/><definition value="Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.&#xD;&#xA;&#xD;&#xA;*Examples:* &#xD;&#xA;&#xD;&#xA; *  ranitidine for Tagamet"/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="therapeutic alternative"/></designation><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="16624"/></property><concept><code value="TB"/><display value="therapeutic brand"/><definition value="Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics&#xD;&#xA;&#xD;&#xA;&gt;&#xD;&#xA;&#xD;&#xA;*Examples:* &#xD;&#xA;&#xD;&#xA; *  Zantac for Tagamet"/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="therapeutic brand"/></designation><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="23105"/></property></concept><concept><code value="TG"/><display value="therapeutic generic"/><definition value="Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands&#xD;&#xA;&#xD;&#xA;&gt;&#xD;&#xA;&#xD;&#xA;*Examples:* &#xD;&#xA;&#xD;&#xA; *  Ranitidine for cimetidine"/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="therapeutic generic"/></designation><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="23106"/></property></concept></concept></concept><concept><code value="F"/><display value="formulary"/><definition value="This substitution was performed or is permitted based on formulary guidelines."/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="formulary"/></designation><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="16625"/></property></concept><concept><code value="N"/><display value="none"/><definition value="No substitution occurred or is permitted."/><designation><language value="en"/><use><system value="http://terminology.hl7.org/CodeSystem/designation-usage"/><code value="display"/></use><value value="none"/></designation><property><code value="status"/><valueCode value="active"/></property><property><code value="internalId"/><valueCode value="16622"/></property></concept></concept></CodeSystem>