v3-ObservationInterpretation
type: CodeSystem
node role: treeRoot
id:
  v: v3-ObservationInterpretation
language:
  v: en
text:
  status:
    v: extensions
  div: Properties This code system defines the following properties for its concepts Name Code URI Type Description Specializes Specializes Coding The child code is a more narrow version of the concept represented by the parent code. I.e. Every child concept is also a valid parent concept. Used to allow determination of subsumption. Must be transitive, irreflexive, antisymmetric. Generalizes Generalizes Coding Inverse of Specializes. Only included as a derived relationship. internalId internalId http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id code The internal identifier for the concept in the HL7 Access database repository. Not Selectable notSelectable http://hl7.org/fhir/concept-properties#notSelectable boolean Indicates that the code is abstract - only intended to be used as a selector for other concepts status status http://hl7.org/fhir/concept-properties#status code A property that indicates the status of the concept. One of active, experimental, deprecated, or retired. deprecationDate deprecationDate http://hl7.org/fhir/concept-properties#deprecationDate dateTime The date at which a concept was deprecated. Concepts that are deprecated but not inactive can still be used, but their use is discouraged. Parent subsumedBy http://hl7.org/fhir/concept-properties#parent code The concept code of a parent concept Concepts This case-sensitive code system http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation defines the following codes in a Is-A hierarchy: Lvl Code Display Definition Deprecated internalId Not Selectable status deprecationDate Parent 1 _GeneticObservationInterpretation GeneticObservationInterpretation Codes that specify interpretation of genetic analysis, such as "positive", "negative", "carrier", "responsive", etc. 22646 true active 2 CAR Carrier The patient is considered as carrier based on the testing results. A carrier is an individual who carries an altered form of a gene which can lead to having a child or offspring …
url:
  v: http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation
identifier:
  system:
    v: urn:ietf:rfc:3986
  value:
    v: urn:oid:2.16.840.1.113883.5.83
version:
  v: 3.0.0
name:
  v: ObservationInterpretation
title:
  v: ObservationInterpretation
status:
  v: active
experimental:
  v: false
date:
  v: 2019-03-20
publisher:
  v: Health Level Seven International
contact:
  telecom:
    system:
      v: url
    value:
      v: http://hl7.org
  telecom:
    system:
      v: email
description:
  v: One or more codes providing a rough qualitative interpretation of the observation, such as "normal" / "abnormal", "low" / "high", "better" / "worse", "resistant" / "susceptible", "expected" / "not expected". The value set is intended to be for ANY use where coded representation of an interpretation is needed.
copyright:
  v: This material derives from the HL7 Terminology THO. THO is copyright ©1989+ Health Level Seven International and is made available under the CC0 designation. For more licensing information see: https://terminology.hl7.org/license
case sensitive:
  v: true
hierarchy meaning:
  v: is-a
content:
  v: complete
property:
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry
    value:
      v: antisymmetric
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity
    value:
      v: transitive
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity
    value:
      v: irreflexive
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable
    value:
      v: true
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind
    value:
      v: Specializes
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName
    value:
      v: Generalizes
  code:
    v: Specializes
  description:
    v: The child code is a more narrow version of the concept represented by the parent code. I.e. Every child concept is also a valid parent concept. Used to allow determination of subsumption. Must be transitive, irreflexive, antisymmetric.
  type:
    v: Coding
property:
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry
    value:
      v: antisymmetric
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity
    value:
      v: transitive
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity
    value:
      v: irreflexive
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable
    value:
      v: true
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind
    value:
      v: Generalizes
  extension:
    url:
      v: http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName
    value:
      v: Specializes
  code:
    v: Generalizes
  description:
    v: Inverse of Specializes. Only included as a derived relationship.
  type:
    v: Coding
property:
  code:
    v: internalId
  uri:
    v: http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id
  description:
    v: The internal identifier for the concept in the HL7 Access database repository.
  type:
    v: code
property:
  code:
    v: notSelectable
  uri:
    v: http://hl7.org/fhir/concept-properties#notSelectable
  description:
    v: Indicates that the code is abstract - only intended to be used as a selector for other concepts
  type:
    v: boolean
property:
  code:
    v: status
  uri:
    v: http://hl7.org/fhir/concept-properties#status
  description:
    v: A property that indicates the status of the concept. One of active, experimental, deprecated, or retired.
  type:
    v: code
property:
  code:
    v: deprecationDate
  uri:
    v: http://hl7.org/fhir/concept-properties#deprecationDate
  description:
    v: The date at which a concept was deprecated. Concepts that are deprecated but not inactive can still be used, but their use is discouraged.
  type:
    v: dateTime
property:
  code:
    v: subsumedBy
  uri:
    v: http://hl7.org/fhir/concept-properties#parent
  description:
    v: The concept code of a parent concept
  type:
    v: code
concept:
  code:
    v: _GeneticObservationInterpretation
  display:
    v: GeneticObservationInterpretation
  definition:
    v: Codes that specify interpretation of genetic analysis, such as "positive", "negative", "carrier", "responsive", etc.
  property:
    code:
      v: notSelectable
    value:
      v: true
  property:
    code:
      v: status
    value:
      v: active
  property:
    code:
      v: internalId
    value:
      v: 22646
concept:
  code:
    v: _ObservationInterpretationChange
  display:
    v: ObservationInterpretationChange
  definition:
    v: Interpretations of change of quantity and/or severity. At most one of B or W and one of U or D allowed.
  property:
    code:
      v: notSelectable
    value:
      v: true

code:
  v: status
value:
  v: active

code:
  v: internalId
value:
  v: 21090

code:
  v: _ObservationInterpretationExceptions
display:
  v: ObservationInterpretationExceptions
definition:
  v: Technical exceptions resulting in the inability to provide an interpretation. At most one allowed. Does not imply normality or severity.
property:
  code:
    v: notSelectable
  value:
    v: true
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 21091

code:
  v: _ObservationInterpretationNormality
display:
  v: ObservationInterpretationNormality
definition:
  v: Interpretation of normality or degree of abnormality (including critical or "alert" level). Concepts in this category are mutually exclusive, i.e., at most one is allowed.
property:
  code:
    v: notSelectable
  value:
    v: true
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 21092

code:
  v: _ObservationInterpretationSusceptibility
display:
  v: ObservationInterpretationSusceptibility
definition:
  v: Interpretations of anti-microbial susceptibility testing results (microbiology). At most one allowed.
property:
  code:
    v: notSelectable
  value:
    v: true
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 21093

code:
  v: EX
display:
  v: outside threshold
definition:
  v: The observation/test result is interpreted as being outside the inclusion range for a particular protocol within which the result is being reported. **Example:** A positive result on a Hepatitis screening test. *Open Issue:* EX, HX, LX: These three concepts do not seem to meet a clear need in the vocabulary, and their use in observation interpretation appears likely to be covered by other existing concepts (e.g., A, H, L). The only apparent significant difference is their reference to use in protocols for exclusion of study subjects. These concepts/codes were proposed by RCRIM for use in the CTLaboratory message. They were submitted and approved in the November 2005 Harmonization cycle in proposal "030103C\_VOCAB\_RCRIM\_l\_quade\_RCRIM Obs Interp\_20051028154455". However, this proposal was not fully implemented in the vocabulary. The proposal recommended creation of the x\_ClinicalResearchExclusion domain in ObservationInterpretation with a value set including those three concepts/codes, but there is no subdomain of that name or equivalent with a binding to either of the value sets that contain these concepts/codes. Members of the OO WG have recently attempted to contact members of RCRIM regarding these concepts, both by email and at the recent WGM in Atlanta, without response. It is felt by OO that the best course of action to take at this time is to add this comprehensive Open Issue rather than deprecate these three concepts at this time, until further discussion is held.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 21634

code:
  v: HM
display:
  v: Hold for Medical Review
definition:
  v: Hold for Medical Review *Usage Note:* This code is not intended for use in V3 artifacts. It is included in the code system to maintain alignment with the V2 Table 0078 "Interpretation Codes."
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2016-11-10
property:
  code:
    v: internalId
  value:
    v: 23790

code:
  v: ObservationInterpretationDetection
display:
  v: ObservationInterpretationDetection
definition:
  v: Interpretations of the presence or absence of a component / analyte or organism in a test or of a sign in a clinical observation. In keeping with laboratory data processing practice, these concepts provide a categorical interpretation of the "meaning" of the quantitative value for the same observation.
property:
  code:
    v: notSelectable
  value:
    v: true
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 22805

code:
  v: ObservationInterpretationExpectation
display:
  v: ObservationInterpretationExpectation
definition:
  v: Interpretation of the observed result taking into account additional information (contraindicators) about the patient's situation. Concepts in this category are mutually exclusive, i.e., at most one is allowed.
property:
  code:
    v: notSelectable
  value:
    v: true
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23723

code:
  v: OBX
display:
  v: Interpretation qualifiers in separate OBX segments
definition:
  v: Interpretation qualifiers in separate OBX segments *Usage Note:* This code is not intended for use in V3 artifacts. It is included in the code system to maintain alignment with the V2 Table 0078 "Interpretation Codes."
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2016-11-10
property:
  code:
    v: internalId
  value:
    v: 23789

code:
  v: ReactivityObservationInterpretation
display:
  v: ReactivityObservationInterpretation
definition:
  v: Interpretations of the presence and level of reactivity of the specified component / analyte with the reagent in the performed laboratory test.
property:
  code:
    v: notSelectable
  value:
    v: true
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23568

code:
  v: CAR
display:
  v: Carrier
definition:
  v: The patient is considered as carrier based on the testing results. A carrier is an individual who carries an altered form of a gene which can lead to having a child or offspring in future generations with a genetic disorder.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23559
property:
  code:
    v: subsumedBy
  value:
    v: _GeneticObservationInterpretation

code:
  v: Carrier
display:
  v: Carrier
definition:
  v: The patient is considered as carrier based on the testing results. A carrier is an individual who carries an altered form of a gene which can lead to having a child or offspring in future generations with a genetic disorder. ***Deprecation Comment:*** This code is currently the same string as the print name for this concept and is inconsistent with the conventions being used for the other codes in the coding system, as it is a full word with initial capitalization, rather than an all upper case mnemonic. The recommendation from OO is to deprecate the code "Carrier" and to add "CAR" as the new active code representation for this concept.
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2013-07-28
property:
  code:
    v: internalId
  value:
    v: 22647
property:
  code:
    v: subsumedBy
  value:
    v: _GeneticObservationInterpretation

code:
  v: B
display:
  v: Better
definition:
  v: The current result or observation value has improved compared to the previous result or observation value (the change is significant as defined in the respective test procedure). \[Note: This can be applied to quantitative or qualitative observations.\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10215
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationChange

code:
  v: D
display:
  v: Significant change down
definition:
  v: The current result has decreased from the previous result for a quantitative observation (the change is significant as defined in the respective test procedure).
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10218
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationChange

code:
  v: U
display:
  v: Significant change up
definition:
  v: The current result has increased from the previous result for a quantitative observation (the change is significant as defined in the respective test procedure).
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10217
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationChange

code:
  v: W
display:
  v: Worse
definition:
  v: The current result or observation value has degraded compared to the previous result or observation value (the change is significant as defined in the respective test procedure). \[Note: This can be applied to quantitative or qualitative observations.\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10216
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationChange

code:
  v: <
display:
  v: Off scale low
definition:
  v: The result is below the minimum detection limit (the test procedure or equipment is the limiting factor). Synonyms: Below analytical limit, low off scale.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10226
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationExceptions

code:
  v: >
display:
  v: Off scale high
definition:
  v: The result is above the maximum quantifiable limit (the test procedure or equipment is the limiting factor). Synonyms: Above analytical limit, high off scale.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10227
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationExceptions

code:
  v: AC
display:
  v: Anti-complementary substances present
definition:
  v: A valid result cannot be obtained for the specified component / analyte due to the presence of anti-complementary substances in the sample. ***Deprecation Comment:*** This code is being deprecated to match the status in V2 Table 0078 "Interpretation Codes.
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2016-11-10
property:
  code:
    v: internalId
  value:
    v: 23564
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationExceptions

code:
  v: IE
display:
  v: Insufficient evidence
definition:
  v: There is insufficient evidence that the species in question is a good target for therapy with the drug. A categorical interpretation is not possible. \[Note: A MIC with "IE" and/or a comment may be reported (without an accompanying S, I or R-categorization).\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23567
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationExceptions
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationSusceptibility

code:
  v: QCF
display:
  v: Quality control failure
definition:
  v: A result cannot be considered valid for the specified component / analyte or organism due to failure in the quality control testing component. ***Deprecation Comment:*** This code is being deprecated to match the status in V2 Table 0078 "Interpretation Codes.
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2016-11-10
property:
  code:
    v: internalId
  value:
    v: 23565
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationExceptions

code:
  v: TOX
display:
  v: Cytotoxic substance present
definition:
  v: A valid result cannot be obtained for the specified organism or cell line due to the presence of cytotoxic substances in the sample or culture. ***Deprecation Comment:*** This code is being deprecated to match the status in V2 Table 0078 "Interpretation Codes.
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2016-11-10
property:
  code:
    v: internalId
  value:
    v: 23566
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationExceptions

code:
  v: A
display:
  v: Abnormal
definition:
  v: The result or observation value is outside the reference range or expected norm (as defined for the respective test procedure). \[Note: Typically applies to non-numeric results.\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10208
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationNormality

code:
  v: N
display:
  v: Normal
definition:
  v: The result or observation value is within the reference range or expected norm (as defined for the respective test procedure). \[Note: Applies to numeric or non-numeric results.\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10207
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationNormality

code:
  v: I
display:
  v: Intermediate
definition:
  v: Bacterial strain inhibited in vitro by a concentration of an antimicrobial agent that is associated with uncertain therapeutic effect. Reference: CLSI (http://www.clsi.org/Content/NavigationMenu/Resources/HarmonizedTerminologyDatabase/Harmonized\_Terminolo.htm) Projects: ISO 20776-1, ISO 20776-2 \[Note 1: Bacterial strains are categorized as intermediate by applying the appropriate breakpoints in a defined phenotypic test system.\] \[Note 2: This class of susceptibility implies that an infection due to the isolate can be appropriately treated in body sites where the drugs are physiologically concentrated or when a high dosage of drug can be used.\] \[Note 3: This class also indicates a "buffer zone," to prevent small, uncontrolled, technical factors from causing major discrepancies in interpretations.\] \[Note 4: These breakpoints can be altered due to changes in circumstances (e.g., changes in commonly used drug dosages, emergence of new resistance mechanisms).\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10221
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationSusceptibility

code:
  v: MS
display:
  v: moderately susceptible
definition:
  v: The patient is considered as carrier based on the testing results. A carrier is an individual who carries an altered form of a gene which can lead to having a child or offspring in future generations with a genetic disorder. ***Deprecation Comment:*** This antimicrobial susceptibility test interpretation concept is recommended by OO to be deprecated as it is no longer recommended for use in susceptibility testing by CLSI (reference CLSI document M100-S22; Vol. 32 No.3; CLSI Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Second Informational Supplement. Jan 2012).
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2013-07-28
property:
  code:
    v: internalId
  value:
    v: 10222
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationSusceptibility

code:
  v: NCL
display:
  v: No CLSI defined breakpoint
definition:
  v: Use when not enough clinical trial data published by the Clinical and Laboratory Standards Institutes (CLSI) is available to establish the breakpoints for susceptible / intermediate and resistant.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23886
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationSusceptibility

code:
  v: NS
display:
  v: Non-susceptible
definition:
  v: A category used for isolates for which only a susceptible interpretive criterion has been designated because of the absence or rare occurrence of resistant strains. Isolates that have MICs above or zone diameters below the value indicated for the susceptible breakpoint should be reported as non-susceptible. NOTE 1: An isolate that is interpreted as non-susceptible does not necessarily mean that the isolate has a resistance mechanism. It is possible that isolates with MICs above the susceptible breakpoint that lack resistance mechanisms may be encountered within the wild-type distribution subsequent to the time the susceptible-only breakpoint is set. NOTE 2: For strains yielding results in the "nonsusceptible" category, organism identification and antimicrobial susceptibility test results should be confirmed. Synonym: decreased susceptibility.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23557
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationSusceptibility

code:
  v: R
display:
  v: Resistant
definition:
  v: Bacterial strain inhibited in vitro by a concentration of an antimicrobial agent that is associated with a high likelihood of therapeutic failure. Reference: CLSI (http://www.clsi.org/Content/NavigationMenu/Resources/HarmonizedTerminologyDatabase/Harmonized\_Terminolo.htm) Projects: ISO 20776-1, ISO 20776-2 \[Note 1: Bacterial strains are categorized as resistant by applying the appropriate breakpoints in a defined phenotypic test system.\] \[Note 2: This breakpoint can be altered due to changes in circumstances (e.g., changes in commonly used drug dosages, emergence of new resistance mechanisms).\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10220
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationSusceptibility

code:
  v: S
display:
  v: Susceptible
definition:
  v: Bacterial strain inhibited by in vitro concentration of an antimicrobial agent that is associated with a high likelihood of therapeutic success. Reference: CLSI (http://www.clsi.org/Content/NavigationMenu/Resources/HarmonizedTerminologyDatabase/Harmonized\_Terminolo.htm) Synonym (earlier term): Sensitive Projects: ISO 20776-1, ISO 20776-2 \[Note 1: Bacterial strains are categorized as susceptible by applying the appropriate breakpoints in a defined phenotypic system.\] \[Note 2: This breakpoint can be altered due to changes in circumstances (e.g., changes in commonly used drug dosages, emergence of new resistance mechanisms).\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10223
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationSusceptibility

code:
  v: VS
display:
  v: very susceptible
definition:
  v: The patient is considered as carrier based on the testing results. A carrier is an individual who carries an altered form of a gene which can lead to having a child or offspring in future generations with a genetic disorder. ***Deprecation Comment:*** This antimicrobial susceptibility test interpretation concept is recommended by OO to be deprecated as it is no longer recommended for use in susceptibility testing by CLSI (reference CLSI document M100-S22; Vol. 32 No.3; CLSI Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Second Informational Supplement. Jan 2012).
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2013-07-28
property:
  code:
    v: internalId
  value:
    v: 10224
property:
  code:
    v: subsumedBy
  value:
    v: _ObservationInterpretationSusceptibility

code:
  v: AA
display:
  v: Critical abnormal
definition:
  v: The result or observation value is outside a reference range or expected norm at a level at which immediate action should be considered for patient safety (as defined for the respective test procedure). \[Note: Typically applies to non-numeric results. Analogous to critical/panic limits for numeric results.\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10211
property:
  code:
    v: subsumedBy
  value:
    v: A

code:
  v: H
display:
  v: High
definition:
  v: The result for a quantitative observation is above the upper limit of the reference range (as defined for the respective test procedure). Synonym: Above high normal
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10210
property:
  code:
    v: subsumedBy
  value:
    v: A

code:
  v: L
display:
  v: Low
definition:
  v: The result for a quantitative observation is below the lower limit of the reference range (as defined for the respective test procedure). Synonym: Below low normal
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10209
property:
  code:
    v: subsumedBy
  value:
    v: A

code:
  v: HH
display:
  v: Critical high
definition:
  v: The result for a quantitative observation is above a reference level at which immediate action should be considered for patient safety (as defined for the respective test procedure). Synonym: Above upper panic limits.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10213
property:
  code:
    v: subsumedBy
  value:
    v: AA
property:
  code:
    v: subsumedBy
  value:
    v: H>
property:
  code:
    v: subsumedBy
  value:
    v: HU

code:
  v: LL
display:
  v: Critical low
definition:
  v: The result for a quantitative observation is below a reference level at which immediate action should be considered for patient safety (as defined for the respective test procedure). Synonym: Below lower panic limits.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 10212
property:
  code:
    v: subsumedBy
  value:
    v: AA
property:
  code:
    v: subsumedBy
  value:
    v: L<
property:
  code:
    v: subsumedBy
  value:
    v: LU

code:
  v: HX
display:
  v: above high threshold
definition:
  v: The observation/test result is interpreted as being outside the inclusion range for a particular protocol within which the result is being reported. **Example:** A positive result on a Hepatitis screening test. *Open Issue:* EX, HX, LX: These three concepts do not seem to meet a clear need in the vocabulary, and their use in observation interpretation appears likely to be covered by other existing concepts (e.g., A, H, L). The only apparent significant difference is their reference to use in protocols for exclusion of study subjects. These concepts/codes were proposed by RCRIM for use in the CTLaboratory message. They were submitted and approved in the November 2005 Harmonization cycle in proposal "030103C\_VOCAB\_RCRIM\_l\_quade\_RCRIM Obs Interp\_20051028154455". However, this proposal was not fully implemented in the vocabulary. The proposal recommended creation of the x\_ClinicalResearchExclusion domain in ObservationInterpretation with a value set including those three concepts/codes, but there is no subdomain of that name or equivalent with a binding to either of the value sets that contain these concepts/codes. Members of the OO WG have recently attempted to contact members of RCRIM regarding these concepts, both by email and at the recent WGM in Atlanta, without response. It is felt by OO that the best course of action to take at this time is to add this comprehensive Open Issue rather than deprecate these three concepts at this time, until further discussion is held.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 21636
property:
  code:
    v: subsumedBy
  value:
    v: EX

code:
  v: LX
display:
  v: below low threshold
definition:
  v: The numeric observation/test result is interpreted as being below the low threshold value for a particular protocol within which the result is being reported. **Example:** A Total White Blood Cell Count falling below a protocol-defined threshold value of 3000/mm^3 *Open Issue:* EX, HX, LX: These three concepts do not seem to meet a clear need in the vocabulary, and their use in observation interpretation appears likely to be covered by other existing concepts (e.g., A, H, L). The only apparent significant difference is their reference to use in protocols for exclusion of study subjects. These concepts/codes were proposed by RCRIM for use in the CTLaboratory message. They were submitted and approved in the November 2005 Harmonization cycle in proposal "030103C\_VOCAB\_RCRIM\_l\_quade\_RCRIM Obs Interp\_20051028154455". However, this proposal was not fully implemented in the vocabulary. The proposal recommended creation of the x\_ClinicalResearchExclusion domain in ObservationInterpretation with a value set including those three concepts/codes, but there is no subdomain of that name or equivalent with a binding to either of the value sets that contain these concepts/codes. Members of the OO WG have recently attempted to contact members of RCRIM regarding these concepts, both by email and at the recent WGM in Atlanta, without response. It is felt by OO that the best course of action to take at this time is to add this comprehensive Open Issue rather than deprecate these three concepts at this time, until further discussion is held.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 21635
property:
  code:
    v: subsumedBy
  value:
    v: EX

code:
  v: H>
display:
  v: Significantly high
definition:
  v: A test result that is significantly higher than the reference (normal) or therapeutic interval, but has not reached the critically high value and might need special attention, as defined by the laboratory or the clinician. \[Note: This level is situated between 'H' and 'HH'.\] *Deprecation Comment:* The code 'H>' is being deprecated in order to align with the use of the code 'HU' for "Very high" in V2 Table 0078 "Interpretation Codes". \[Note: The use of code 'H>' is non-preferred, as this code is deprecated and on track to be retired; use code 'HU' instead.
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2015-03-23
property:
  code:
    v: internalId
  value:
    v: 23560
property:
  code:
    v: subsumedBy
  value:
    v: H

code:
  v: HU
display:
  v: Significantly high
definition:
  v: A test result that is significantly higher than the reference (normal) or therapeutic interval, but has not reached the critically high value and might need special attention, as defined by the laboratory or the clinician.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23742
property:
  code:
    v: subsumedBy
  value:
    v: H

code:
  v: E
display:
  v: Equivocal
definition:
  v: The test or procedure was successfully performed, but the results are borderline and can neither be declared positive / negative nor detected / not detected according to the current established criteria.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23732
property:
  code:
    v: subsumedBy
  value:
    v: IND

code:
  v: L<
display:
  v: Significantly low
definition:
  v: A test result that is significantly lower than the reference (normal) or therapeutic interval, but has not reached the critically low value and might need special attention, as defined by the laboratory or the clinician. \[Note: This level is situated between 'L' and 'LL'.\] *Deprecation Comment:* The code 'L<' is being deprecated in order to align with the use of the code 'LU' for "Very low" in V2 Table 0078 "Interpretation Codes". \[Note: The use of code 'L<' is non-preferred, as this code is deprecated and on track to be retired; use code 'LU' instead.
property:
  code:
    v: status
  value:
    v: deprecated
property:
  code:
    v: deprecationDate
  value:
    v: 2015-03-23
property:
  code:
    v: internalId
  value:
    v: 23561
property:
  code:
    v: subsumedBy
  value:
    v: L

code:
  v: LU
display:
  v: Significantly low
definition:
  v: A test result that is significantly lower than the reference (normal) or therapeutic interval, but has not reached the critically low value and might need special attention, as defined by the laboratory or the clinician.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23743
property:
  code:
    v: subsumedBy
  value:
    v: L

code:
  v: ND
display:
  v: Not detected
definition:
  v: The presence of the specified component / analyte, organism or clinical sign could not be determined within the limit of detection of the performed test or procedure.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23563
property:
  code:
    v: subsumedBy
  value:
    v: NEG

code:
  v: IND
display:
  v: Indeterminate
definition:
  v: The specified component / analyte, organism or clinical sign could neither be declared positive / negative nor detected / not detected by the performed test or procedure. *Usage Note:* For example, if the specimen was degraded, poorly processed, or was missing the required anatomic structures, then "indeterminate" (i.e. "cannot be determined") is the appropriate response, not "equivocal".
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 22807
property:
  code:
    v: subsumedBy
  value:
    v: ObservationInterpretationDetection

code:
  v: NEG
display:
  v: Negative
definition:
  v: An absence finding of the specified component / analyte, organism or clinical sign based on the established threshold of the performed test or procedure. \[Note: Negative does not necessarily imply the complete absence of the specified item.\]
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 22808
property:
  code:
    v: subsumedBy
  value:
    v: ObservationInterpretationDetection

code:
  v: POS
display:
  v: Positive
definition:
  v: A presence finding of the specified component / analyte, organism or clinical sign based on the established threshold of the performed test or procedure.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 22806
property:
  code:
    v: subsumedBy
  value:
    v: ObservationInterpretationDetection

code:
  v: EXP
display:
  v: Expected
definition:
  v: This result has been evaluated in light of known contraindicators. Once those contraindicators have been taken into account the result is determined to be "Expected" (e.g., presence of drugs in a patient that is taking prescription medication for pain management).
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23724
property:
  code:
    v: subsumedBy
  value:
    v: ObservationInterpretationExpectation

code:
  v: UNE
display:
  v: Unexpected
definition:
  v: This result has been evaluated in light of known contraindicators. Once those contraindicators have been taken into account the result is determined to be "Unexpected" (e.g., presence of non-prescribed drugs in a patient that is taking prescription medication for pain management).
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23725
property:
  code:
    v: subsumedBy
  value:
    v: ObservationInterpretationExpectation

code:
  v: DET
display:
  v: Detected
definition:
  v: The measurement of the specified component / analyte, organism or clinical sign above the limit of detection of the performed test or procedure.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23562
property:
  code:
    v: subsumedBy
  value:
    v: POS

code:
  v: SYN-R
display:
  v: Synergy - resistant
definition:
  v: A category for isolates where the bacteria (e.g. enterococci) are not susceptible in vitro to a combination therapy (e.g., high-level aminoglycoside and cell wall active agent). This is predictive that this combination therapy will not be effective. *Usage Note:* Since the use of penicillin or ampicillin alone often results in treatment failure of serious enterococcal or other bacterial infections, combination therapy is usually indicated to enhance bactericidal activity. The synergy between a cell wall active agent (such as penicillin, ampicillin, or vancomycin) and an aminoglycoside (such as gentamicin, kanamycin or streptomycin) is best predicted by screening for high-level bacterial resistance to the aminoglycoside. *Open Issue:* The print name of the code is very general and the description is very specific to a pair of classes of agents, which may lead to confusion of these concepts in the future should other synergies be found.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23621
property:
  code:
    v: subsumedBy
  value:
    v: R

code:
  v: NR
display:
  v: Non-reactive
definition:
  v: An absence finding used to indicate that the specified component / analyte did not react measurably with the reagent.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23569
property:
  code:
    v: subsumedBy
  value:
    v: ReactivityObservationInterpretation

code:
  v: RR
display:
  v: Reactive
definition:
  v: A presence finding used to indicate that the specified component / analyte reacted with the reagent above the reliably measurable limit of the performed test.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23570
property:
  code:
    v: subsumedBy
  value:
    v: ReactivityObservationInterpretation

code:
  v: WR
display:
  v: Weakly reactive
definition:
  v: A weighted presence finding used to indicate that the specified component / analyte reacted with the reagent, but below the reliably measurable limit of the performed test.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23571
property:
  code:
    v: subsumedBy
  value:
    v: RR

code:
  v: SDD
display:
  v: Susceptible-dose dependent
definition:
  v: A category that includes isolates with antimicrobial agent minimum inhibitory concentrations (MICs) that approach usually attainable blood and tissue levels and for which response rates may be lower than for susceptible isolates. Reference: CLSI document M44-A2 2009 "Method for antifungal disk diffusion susceptibility testing of yeasts; approved guideline - second edition" - page 2.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23558
property:
  code:
    v: subsumedBy
  value:
    v: S

code:
  v: SYN-S
display:
  v: Synergy - susceptible
definition:
  v: A category for isolates where the bacteria (e.g. enterococci) are susceptible in vitro to a combination therapy (e.g., high-level aminoglycoside and cell wall active agent). This is predictive that this combination therapy will be effective. *Usage Note:* Since the use of penicillin or ampicillin alone often results in treatment failure of serious enterococcal or other bacterial infections, combination therapy is usually indicated to enhance bactericidal activity. The synergy between a cell wall active agent (such as penicillin, ampicillin, or vancomycin) and an aminoglycoside (such as gentamicin, kanamycin or streptomycin) is best predicted by screening for high-level bacterial resistance to the aminoglycoside. *Open Issue:* The print name of the code is very general and the description is very specific to a pair of classes of agents, which may lead to confusion of these concepts in the future should other synergies be found.
property:
  code:
    v: status
  value:
    v: active
property:
  code:
    v: internalId
  value:
    v: 23620
property:
  code:
    v: subsumedBy
  value:
    v: S