@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution> a fhir:CodeSystem ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "v3-substanceAdminSubstitution"] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\" xml:lang=\"en\" lang=\"en\"><p><b>Properties</b></p><p><b>This code system defines the following properties for its concepts</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>URI</b></td><td><b>Type</b></td><td><b>Description</b></td></tr><tr><td>Specializes</td><td/><td>Coding</td><td>The child code is a more narrow version of the concept represented by the parent code.  I.e. Every child concept is also a valid parent concept.  Used to allow determination of subsumption.  Must be transitive, irreflexive, antisymmetric.</td></tr><tr><td>Generalizes</td><td/><td>Coding</td><td>Inverse of Specializes.  Only included as a derived relationship.</td></tr><tr><td>internalId</td><td>http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id</td><td>code</td><td>The internal identifier for the concept in the HL7 Access database repository.</td></tr><tr><td>notSelectable</td><td>http://hl7.org/fhir/concept-properties#notSelectable</td><td>boolean</td><td>Indicates that the code is abstract - only intended to be used as a selector for other concepts</td></tr><tr><td>status</td><td>http://hl7.org/fhir/concept-properties#status</td><td>code</td><td>Designation of a concept's state. Normally is not populated unless the state is retired.</td></tr></table><p><b>Concepts</b></p><p>This case-sensitive code system <code>http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution</code> defines the following codes in a Is-A hierarchy:</p><table class=\"codes\"><tr><td><b>Lvl</b></td><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td><td><b>internalId</b></td><td><b>Not Selectable</b></td><td><b>status</b></td></tr><tr><td>1</td><td style=\"white-space:nowrap\">_ActSubstanceAdminSubstitutionCode<a name=\"v3-substanceAdminSubstitution-_ActSubstanceAdminSubstitutionCode\"> </a></td><td>ActSubstanceAdminSubstitutionCode</td><td><div><p><strong>Description:</strong> Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects.</p>\n</div></td><td>21284</td><td>true</td><td>active</td></tr><tr><td>2</td><td style=\"white-space:nowrap\">  E<a name=\"v3-substanceAdminSubstitution-E\"> </a></td><td>equivalent</td><td><div><p><strong>Description:</strong> Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product.</p>\n</div></td><td>23107</td><td/><td>active</td></tr><tr><td>3</td><td style=\"white-space:nowrap\">    EC<a name=\"v3-substanceAdminSubstitution-EC\"> </a></td><td>equivalent composition</td><td><div><p><strong>Description:</strong></p>\n<p>Substitution occurred or is permitted with another product that is a:</p>\n<ul>\n<li>pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester</li>\n<li>pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration</li>\n</ul>\n<p><em>Examples:</em></p>\n<ul>\n<li><em>Pharmaceutical alternative:</em> Erythromycin Ethylsuccinate for Erythromycin Stearate</li>\n<li><em>Pharmaceutical equivalent:</em> Lisonpril for Zestril</li>\n</ul>\n</div></td><td>23108</td><td/><td>active</td></tr><tr><td>4</td><td style=\"white-space:nowrap\">      BC<a name=\"v3-substanceAdminSubstitution-BC\"> </a></td><td>brand composition</td><td><div><p><strong>Description:</strong></p>\n<p>Substitution occurred or is permitted between equivalent Brands but not Generics</p>\n<p><em>Examples:</em></p>\n<ul>\n<li>Zestril for Prinivil</li>\n<li>Coumadin for Jantoven</li>\n</ul>\n</div></td><td>23109</td><td/><td>active</td></tr><tr><td>4</td><td style=\"white-space:nowrap\">      G<a name=\"v3-substanceAdminSubstitution-G\"> </a></td><td>generic composition</td><td><div><p><strong>Description:</strong> Substitution occurred or is permitted between equivalent Generics but not Brands</p>\n<p><em>Examples:</em></p>\n<ul>\n<li>Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)</li>\n</ul>\n</div></td><td>16623</td><td/><td>active</td></tr><tr><td>3</td><td style=\"white-space:nowrap\">    TE<a name=\"v3-substanceAdminSubstitution-TE\"> </a></td><td>therapeutic alternative</td><td><div><p><strong>Description:</strong> Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.</p>\n<p><em>Examples:</em></p>\n<ul>\n<li>ranitidine for Tagamet</li>\n</ul>\n</div></td><td>16624</td><td/><td>active</td></tr><tr><td>4</td><td style=\"white-space:nowrap\">      TB<a name=\"v3-substanceAdminSubstitution-TB\"> </a></td><td>therapeutic brand</td><td><div><p><strong>Description:</strong> Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics</p>\n<blockquote>\n</blockquote>\n<p><em>Examples:</em></p>\n<ul>\n<li>Zantac for Tagamet</li>\n</ul>\n</div></td><td>23105</td><td/><td>active</td></tr><tr><td>4</td><td style=\"white-space:nowrap\">      TG<a name=\"v3-substanceAdminSubstitution-TG\"> </a></td><td>therapeutic generic</td><td><div><p><strong>Description:</strong> Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands</p>\n<blockquote>\n</blockquote>\n<p><em>Examples:</em></p>\n<ul>\n<li>Ranitidine for cimetidine</li>\n</ul>\n</div></td><td>23106</td><td/><td>active</td></tr><tr><td>2</td><td style=\"white-space:nowrap\">  F<a name=\"v3-substanceAdminSubstitution-F\"> </a></td><td>formulary</td><td><div><p><strong>Description:</strong> This substitution was performed or is permitted based on formulary guidelines.</p>\n</div></td><td>16625</td><td/><td>active</td></tr><tr><td>2</td><td style=\"white-space:nowrap\">  N<a name=\"v3-substanceAdminSubstitution-N\"> </a></td><td>none</td><td><div><p>No substitution occurred or is permitted.</p>\n</div></td><td>16622</td><td/><td>active</td></tr></table></div>"
  ] ; # 
  fhir:url [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-substanceAdminSubstitution"^^xsd:anyURI] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.5.1070" ]
  ] ) ; # 
  fhir:version [ fhir:v "3.0.0"] ; # 
  fhir:name [ fhir:v "SubstanceAdminSubstitution"] ; # 
  fhir:title [ fhir:v "Substance Admin Substitution"] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:experimental [ fhir:v "false"^^xsd:boolean] ; # 
  fhir:date [ fhir:v "2019-03-20"^^xsd:date] ; # 
  fhir:publisher [ fhir:v "Health Level Seven International"] ; # 
  fhir:contact ( [
     fhir:telecom ( [
       fhir:system [ fhir:v "url" ] ;
       fhir:value [ fhir:v "http://hl7.org" ]
     ] [
       fhir:system [ fhir:v "email" ] ;
       fhir:value [ fhir:v "hq@HL7.org" ]
     ] )
  ] ) ; # 
  fhir:description [ fhir:v "Identifies what sort of change is permitted or has occurred between the therapy that was ordered and the therapy that was/will be provided."] ; # 
  fhir:copyright [ fhir:v "This material derives from the HL7 Terminology THO. THO is copyright ©1989+ Health Level Seven International and is made available under the CC0 designation. For more licensing information see: https://terminology.hl7.org/license"] ; # 
  fhir:caseSensitive [ fhir:v "true"^^xsd:boolean] ; # 
  fhir:hierarchyMeaning [ fhir:v "is-a"] ; # 
  fhir:content [ fhir:v "complete"] ; # 
  fhir:property ( [
     fhir:extension ( [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "antisymmetric" ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "transitive" ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "irreflexive" ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "true"^^xsd:boolean ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "Specializes" ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "Generalizes" ]
     ] ) ;
     fhir:code [ fhir:v "Specializes" ] ;
     fhir:description [ fhir:v "The child code is a more narrow version of the concept represented by the parent code.  I.e. Every child concept is also a valid parent concept.  Used to allow determination of subsumption.  Must be transitive, irreflexive, antisymmetric." ] ;
     fhir:type [ fhir:v "Coding" ]
  ] [
     fhir:extension ( [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-symmetry"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "antisymmetric" ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-transitivity"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "transitive" ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-reflexivity"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "irreflexive" ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-isNavigable"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "true"^^xsd:boolean ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-relationshipKind"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "Generalizes" ]
     ] [
       fhir:url [ fhir:v "http://terminology.hl7.org/StructureDefinition/ext-mif-relationship-inverseName"^^xsd:anyURI ] ;
       fhir:value [ fhir:v "Specializes" ]
     ] ) ;
     fhir:code [ fhir:v "Generalizes" ] ;
     fhir:description [ fhir:v "Inverse of Specializes.  Only included as a derived relationship." ] ;
     fhir:type [ fhir:v "Coding" ]
  ] [
     fhir:code [ fhir:v "internalId" ] ;
     fhir:uri [ fhir:v "http://terminology.hl7.org/CodeSystem/utg-concept-properties#v3-internal-id"^^xsd:anyURI ] ;
     fhir:description [ fhir:v "The internal identifier for the concept in the HL7 Access database repository." ] ;
     fhir:type [ fhir:v "code" ]
  ] [
     fhir:code [ fhir:v "notSelectable" ] ;
     fhir:uri [ fhir:v "http://hl7.org/fhir/concept-properties#notSelectable"^^xsd:anyURI ] ;
     fhir:description [ fhir:v "Indicates that the code is abstract - only intended to be used as a selector for other concepts" ] ;
     fhir:type [ fhir:v "boolean" ]
  ] [
     fhir:code [ fhir:v "status" ] ;
     fhir:uri [ fhir:v "http://hl7.org/fhir/concept-properties#status"^^xsd:anyURI ] ;
     fhir:description [ fhir:v "Designation of a concept's state. Normally is not populated unless the state is retired." ] ;
     fhir:type [ fhir:v "code" ]
  ] ) ; # 
  fhir:concept ( [
     fhir:code [ fhir:v "_ActSubstanceAdminSubstitutionCode" ] ;
     fhir:display [ fhir:v "ActSubstanceAdminSubstitutionCode" ] ;
     fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted with another product that may potentially have different ingredients, but having the same biological and therapeutic effects." ] ;
     fhir:property ( [
       fhir:code [ fhir:v "notSelectable" ] ;
       fhir:value [ fhir:v "true"^^xsd:boolean ]
     ] [
       fhir:code [ fhir:v "status" ] ;
       fhir:value [ fhir:v "active" ]
     ] [
       fhir:code [ fhir:v "internalId" ] ;
       fhir:value [ fhir:v "21284" ]
     ] ) ;
     fhir:concept ( [
       fhir:code [ fhir:v "E" ] ;
       fhir:display [ fhir:v "equivalent" ] ;
       fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product." ] ;
       fhir:property ( [
         fhir:code [ fhir:v "status" ] ;
         fhir:value [ fhir:v "active" ]
       ] [
         fhir:code [ fhir:v "internalId" ] ;
         fhir:value [ fhir:v "23107" ]
       ] ) ;
       fhir:concept ( [
         fhir:code [ fhir:v "EC" ] ;
         fhir:display [ fhir:v "equivalent composition" ] ;
         fhir:definition [ fhir:v "**Description:** \r\n\r\nSubstitution occurred or is permitted with another product that is a:\r\n\r\n *  pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester\r\n *  pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration\r\n\r\n*Examples:* \r\n\r\n *  *Pharmaceutical alternative:* Erythromycin Ethylsuccinate for Erythromycin Stearate\r\n *  *Pharmaceutical equivalent:* Lisonpril for Zestril" ] ;
         fhir:property ( [
           fhir:code [ fhir:v "status" ] ;
           fhir:value [ fhir:v "active" ]
         ] [
           fhir:code [ fhir:v "internalId" ] ;
           fhir:value [ fhir:v "23108" ]
         ] ) ;
         fhir:concept ( [
           fhir:code [ fhir:v "BC" ] ;
           fhir:display [ fhir:v "brand composition" ] ;
           fhir:definition [ fhir:v "**Description:** \r\n\r\nSubstitution occurred or is permitted between equivalent Brands but not Generics\r\n\r\n*Examples:* \r\n\r\n *  Zestril for Prinivil\r\n *  Coumadin for Jantoven" ] ;
           fhir:property ( [
             fhir:code [ fhir:v "status" ] ;
             fhir:value [ fhir:v "active" ]
           ] [
             fhir:code [ fhir:v "internalId" ] ;
             fhir:value [ fhir:v "23109" ]
           ] )
         ] [
           fhir:code [ fhir:v "G" ] ;
           fhir:display [ fhir:v "generic composition" ] ;
           fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted between equivalent Generics but not Brands\r\n\r\n*Examples:* \r\n\r\n *  Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)" ] ;
           fhir:property ( [
             fhir:code [ fhir:v "status" ] ;
             fhir:value [ fhir:v "active" ]
           ] [
             fhir:code [ fhir:v "internalId" ] ;
             fhir:value [ fhir:v "16623" ]
           ] )
         ] )
       ] [
         fhir:code [ fhir:v "TE" ] ;
         fhir:display [ fhir:v "therapeutic alternative" ] ;
         fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.\r\n\r\n*Examples:* \r\n\r\n *  ranitidine for Tagamet" ] ;
         fhir:property ( [
           fhir:code [ fhir:v "status" ] ;
           fhir:value [ fhir:v "active" ]
         ] [
           fhir:code [ fhir:v "internalId" ] ;
           fhir:value [ fhir:v "16624" ]
         ] ) ;
         fhir:concept ( [
           fhir:code [ fhir:v "TB" ] ;
           fhir:display [ fhir:v "therapeutic brand" ] ;
           fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics\r\n\r\n>\r\n\r\n*Examples:* \r\n\r\n *  Zantac for Tagamet" ] ;
           fhir:property ( [
             fhir:code [ fhir:v "status" ] ;
             fhir:value [ fhir:v "active" ]
           ] [
             fhir:code [ fhir:v "internalId" ] ;
             fhir:value [ fhir:v "23105" ]
           ] )
         ] [
           fhir:code [ fhir:v "TG" ] ;
           fhir:display [ fhir:v "therapeutic generic" ] ;
           fhir:definition [ fhir:v "**Description:** Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands\r\n\r\n>\r\n\r\n*Examples:* \r\n\r\n *  Ranitidine for cimetidine" ] ;
           fhir:property ( [
             fhir:code [ fhir:v "status" ] ;
             fhir:value [ fhir:v "active" ]
           ] [
             fhir:code [ fhir:v "internalId" ] ;
             fhir:value [ fhir:v "23106" ]
           ] )
         ] )
       ] )
     ] [
       fhir:code [ fhir:v "F" ] ;
       fhir:display [ fhir:v "formulary" ] ;
       fhir:definition [ fhir:v "**Description:** This substitution was performed or is permitted based on formulary guidelines." ] ;
       fhir:property ( [
         fhir:code [ fhir:v "status" ] ;
         fhir:value [ fhir:v "active" ]
       ] [
         fhir:code [ fhir:v "internalId" ] ;
         fhir:value [ fhir:v "16625" ]
       ] )
     ] [
       fhir:code [ fhir:v "N" ] ;
       fhir:display [ fhir:v "none" ] ;
       fhir:definition [ fhir:v "No substitution occurred or is permitted." ] ;
       fhir:property ( [
         fhir:code [ fhir:v "status" ] ;
         fhir:value [ fhir:v "active" ]
       ] [
         fhir:code [ fhir:v "internalId" ] ;
         fhir:value [ fhir:v "16622" ]
       ] )
     ] )
  ] ) . # 

# -------------------------------------------------------------------------------------

